Interaction Of Phytocannabinoids + The Endocannabinoid System (ECS)
What Are The Role Of Neurotransmitters In The Brain?
Adenosine - Dopamine - Seratonin - TRPV-1 - AG2 - Anandamide
In every mammal's body exists an endocannabinoid system and the ECS is spread throughout every major system, acting as a master regulatory hub to bring about homeostasis in the body by connecting the neurological functions of the central nervous system (CNS) with the peripheral nervous system (PNS). The CNS nerves connect to the PNS nerves specifically throughout the:
|
|
The Endocannabinoid System (ESC) Regulates A Mammal's Functions:
COURTESY PIXABAY.COM
|
|
|
Phytocannabinoids in hemp combine with the endocannabinoids manufactured by the human body to operate as neuromodulators activating a litany of regenerative functions at the ECS-endocannabinoid receptor sites.
|
Phytocannabinoid-rich hemp oil can potentially activate the
following neurotransmitters and their respective responses in mammals:
1. Adenosine which helps the body fight inflammation.
2. Dopamine which improves motor control, cognitive function and motivation. Low levels of dopamine are associated with Parkinson's disease.
3. Seratonin (5-HT) whereby hemp oil's cannabidiol can mimic seratonin at their respective receptor sites to bring about anti-anxiety and anti-depressant effects along with possible drug addiction recovery potential. *This is not a drug addiction recovery claim.
4. TRPV-1 (Transient Receptor Potential Vanilloid 1) which can dial down inflammation and relieve sensations of pain and signal the brain of potentially harmful temperature abberations in the body too.
5. AG2 (2-arachidonoylglycerol) when combined with CBD and cannabinoids regulates appetite, immune systems functions and pain management.
6. Anandamide (N-arachidonoylethanolomide or AEA) along with the ingestion of cannabidiol and other cannabinoids in hemp can trigger a biological response whereby the body turns off the enzyme FAAH (fatty acid amide hydrolase) responsible for the degradation of anandamide (nicknamed, the "bliss molecule.)" Sustained anandamide levels improves that euphoric "natural high" also associated with "runner's high." This is a calming yet pleasant mental state non-psychoactive in nature induced two ways, from consuming cannabis or as an after-effect of exercise. Anandamide was isolated and discovered by cannabis scientist Professor Raphael Mechoulam and his colleagues in 1992. [4] [15] [16]
2. Dopamine which improves motor control, cognitive function and motivation. Low levels of dopamine are associated with Parkinson's disease.
3. Seratonin (5-HT) whereby hemp oil's cannabidiol can mimic seratonin at their respective receptor sites to bring about anti-anxiety and anti-depressant effects along with possible drug addiction recovery potential. *This is not a drug addiction recovery claim.
4. TRPV-1 (Transient Receptor Potential Vanilloid 1) which can dial down inflammation and relieve sensations of pain and signal the brain of potentially harmful temperature abberations in the body too.
5. AG2 (2-arachidonoylglycerol) when combined with CBD and cannabinoids regulates appetite, immune systems functions and pain management.
6. Anandamide (N-arachidonoylethanolomide or AEA) along with the ingestion of cannabidiol and other cannabinoids in hemp can trigger a biological response whereby the body turns off the enzyme FAAH (fatty acid amide hydrolase) responsible for the degradation of anandamide (nicknamed, the "bliss molecule.)" Sustained anandamide levels improves that euphoric "natural high" also associated with "runner's high." This is a calming yet pleasant mental state non-psychoactive in nature induced two ways, from consuming cannabis or as an after-effect of exercise. Anandamide was isolated and discovered by cannabis scientist Professor Raphael Mechoulam and his colleagues in 1992. [4] [15] [16]
1] Retrieved by https://www.sciencedirect.com/science/article/pii/B9780080453828000915/. By author Dr. Arno Hazekamp, Bachelor’s diploma in the field of molecular biology from the School of Biology.
[2] Retrieved by Development & Modification of Bioactivity https://www.sciencedirect.com/topics/medicine-and-dentistry/hemp-seed/. By authors Arno Hazekamp, ... Renee L. Ruhaak, in Comprehensive Natural Products II, 2010.
[3] Retrieved by https://en.wikipedia.org/wiki/Cannabidiol/. The definition of "cannabidiol - CBD" From Wikipedia.org, the free encyclopedia.
[4] Retrieved by https://en.wikipedia.org/wiki/Raphael_Mechoulam/. Wikipedia.org, keywords: Raphael Mechoulam.
[5] Retrieved by https://www.nlm.nih.gov/exhibition/chinesemedicine/emperors.html “Courtesy of the National Library of Medicine." CLASSICS OF TRADITIONAL CHINESE MEDICINE.
[6] Retrieved by https://s3.amazonaws.com/hempinc/All-About-Hemp-Plant-HempInc-eBook.pdf/. (This book is for educational purposes only and not for resale or duplication). All About The Hemp Plant - 10 Years Of History. Free downloadable e-book. Available at: https://www.hempinc.com/.
[7] Retrieved by https://www.inverse.com/article/58027-cannflavins-a-and-b-in-cannabis-anti-inflammatory/. A Pain Killing Compound 30 Times Stronger Then Aspirin Revealed in Cannabis. By Peter Hess. Published in July 2019 in the Journal of Phytochemistry.
[8] Retrieved by https://en.wikipedia.org/wiki/Cannabis/. The definition of "Cannabis" according to Wikipedia.org/.
[9] Retrieved by https://onlinelibrary.wiley.com/doi/abs/10.1002/cbdv.200790147/. Cannabidiol – Recent Advances Raphael Mechoulam, Maximilian Peters, Eric Murillo‐Rodriguez, Lumír O. Hanuš. First published: 21 August 2007.
[10] Retrieved by https://www.cancer.gov/publications/dictionaries/cancer-drug/def/cannabidiol/. NCI Drug Dictionary. The definition of "cannabidiol."
[11] Retrieved by https://www.projectcbd.org/guidance/conditions/. Conditions. Project CBD is a non-profit educational news service. We do not sell or distribute any CBD/cannabis products. We appreciate your support.
[12] Retrieved by https://www.ncbi.nlm.nih.gov/pubmed/22625422/. Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid? Fernández-Ruiz J1, Sagredo O, Pazos MR, García C, Pertwee R, Mechoulam R, Martínez-Orgado J.
[13] Retrieved by https://en.wikipedia.org/wiki/Endocannabinoid_system/. Wikipedia.org, keywords: Endocannabinoid System.
[14] Retrieved by https://www.overuc.com/cbd-oil-history/?fbclid=IwAR1cCPef7fSoBvjnoGcE7c969EHd2qzEWMIo0-kqAqqBMd9RSsclxNGWQ1I/. CBD Oil History by Jose Valdez.
[15] Retrieved by https://www.foriawellness.com/blogs/learn/discover-benefits-cbd/. Why Does CBD Work So Well by Genevieve R. Moore PhD.
16] Retrieved by https://en.wikipedia.org/wiki/Anandamide/. Wikipedia.org. Keyword: Anandamide.
[2] Retrieved by Development & Modification of Bioactivity https://www.sciencedirect.com/topics/medicine-and-dentistry/hemp-seed/. By authors Arno Hazekamp, ... Renee L. Ruhaak, in Comprehensive Natural Products II, 2010.
[3] Retrieved by https://en.wikipedia.org/wiki/Cannabidiol/. The definition of "cannabidiol - CBD" From Wikipedia.org, the free encyclopedia.
[4] Retrieved by https://en.wikipedia.org/wiki/Raphael_Mechoulam/. Wikipedia.org, keywords: Raphael Mechoulam.
[5] Retrieved by https://www.nlm.nih.gov/exhibition/chinesemedicine/emperors.html “Courtesy of the National Library of Medicine." CLASSICS OF TRADITIONAL CHINESE MEDICINE.
[6] Retrieved by https://s3.amazonaws.com/hempinc/All-About-Hemp-Plant-HempInc-eBook.pdf/. (This book is for educational purposes only and not for resale or duplication). All About The Hemp Plant - 10 Years Of History. Free downloadable e-book. Available at: https://www.hempinc.com/.
[7] Retrieved by https://www.inverse.com/article/58027-cannflavins-a-and-b-in-cannabis-anti-inflammatory/. A Pain Killing Compound 30 Times Stronger Then Aspirin Revealed in Cannabis. By Peter Hess. Published in July 2019 in the Journal of Phytochemistry.
[8] Retrieved by https://en.wikipedia.org/wiki/Cannabis/. The definition of "Cannabis" according to Wikipedia.org/.
[9] Retrieved by https://onlinelibrary.wiley.com/doi/abs/10.1002/cbdv.200790147/. Cannabidiol – Recent Advances Raphael Mechoulam, Maximilian Peters, Eric Murillo‐Rodriguez, Lumír O. Hanuš. First published: 21 August 2007.
[10] Retrieved by https://www.cancer.gov/publications/dictionaries/cancer-drug/def/cannabidiol/. NCI Drug Dictionary. The definition of "cannabidiol."
[11] Retrieved by https://www.projectcbd.org/guidance/conditions/. Conditions. Project CBD is a non-profit educational news service. We do not sell or distribute any CBD/cannabis products. We appreciate your support.
[12] Retrieved by https://www.ncbi.nlm.nih.gov/pubmed/22625422/. Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid? Fernández-Ruiz J1, Sagredo O, Pazos MR, García C, Pertwee R, Mechoulam R, Martínez-Orgado J.
[13] Retrieved by https://en.wikipedia.org/wiki/Endocannabinoid_system/. Wikipedia.org, keywords: Endocannabinoid System.
[14] Retrieved by https://www.overuc.com/cbd-oil-history/?fbclid=IwAR1cCPef7fSoBvjnoGcE7c969EHd2qzEWMIo0-kqAqqBMd9RSsclxNGWQ1I/. CBD Oil History by Jose Valdez.
[15] Retrieved by https://www.foriawellness.com/blogs/learn/discover-benefits-cbd/. Why Does CBD Work So Well by Genevieve R. Moore PhD.
16] Retrieved by https://en.wikipedia.org/wiki/Anandamide/. Wikipedia.org. Keyword: Anandamide.
