What The Heck Are Cannflavin A & B?
by Cindy Trethewey
|
What Are Flavonoids?Formed inside the cannabis trichomes, as well as in other plants, flavonoids are polyphenolic molecules containing 15-carbon atoms with cell signalling talents and antioxidant potentialities. Part of the holistic charm of flavonoids is their sheer abundance throughout the plant kingdom, their unraveling medicinal potentials, and their water-soluble permeability. Flavonoids studies show their propensity to function as a natural anti-inflammatory agent in mammal models.
|
Flavonoids are the chemicals that give plants their pigments, flavors and aromas much like terpenes. For instance, the purple hairs in cannabis or the red in a tomato are due to the flavonoid content. Just as the plumes and feathers of the bird kingdom helps to attract a potential mate, the same can be said of the colors in plants, because their unique flavonoids are what nature uses to attract pollenating insects to plants.
Flavonoids Can Be Divided Into Six Common Major Subtypes.
|
|
Science Is Just Beginning To Unlock The Full Potential Of Flavonoids.
Suggested Preliminary Research Reveals, Flavonoids May Show Many Potential Future Health Benefits:
|
|
|
Flavonoids Are Found Abundantly In Nature.
|
|
Little-Known Flavonoids Cannflavin A & B From Cannabis Sativa L. Are
Showing More Anti-Inflammatory Promise Than CBD-Cannabidiol!
Are prenylated flavones, cannaflavin A & B from Cannabis sativa L. the new frontier in natural cannabinoid anti-inflammatory medicines of the future? Tariq Akhtar, Ph.D. assistant professor of molecular and cellular biology seems to think so. He participated in the isolation study done on the 2 flavone compounds at the Univ. of Guelph in Ontario, in August of 2019 as published in Phytochemistry. [6][11]
Tariq said, “These molecules are non-psychoactive and they target the inflammation at the source, making them ideal painkillers.” In fact, Tariq and his team of researchers drew the conclusion that they have found "A Pain-Killing Compound 30x Stronger Than Aspirin Is Produced in Cannabis." [6]
Although little is known about the pathway of their biosynthesis, Tariq is hopeful that patients of the future will have opioid-free choices with these two ideal cannflavins A & B for a potentially intense and targeted anti-inflammatory response. Tariq and colleagues have sucessfully isolated the two flavones. They managed to replicate them in synthetic form and patents are now pending for these two wonder flavones.
Regardless of whether or not you support or oppose the isolation of genetic plant compounds for exclusive private profiteering, the point remains that this is happening on a grand scale rather furiously as cannabis technologies unfold at a rapid pace. [6][11]
The way it looks we are only touching the tip of the iceberg concerning cannabis research and development for future holistic medicines. These two distinct flavonoids, cannflavin A & B found exclusively in cannabis are gaining attention for their superior anti-inflammatory potential in animal models.
Few controlled studies on humans have been designated for cannabis research of any nature, but over 10K preclinical studies exist for cannabis. Tragically to date, only one synthetic drug with a CBD-cannabidiol cannabis derivative has been approved by the FDA for seizure patients, called EPIDIOLEX. Little is known about the long-term possible drug side-effects of EPIDIOLEX. It's too early to tell. But the short-term side-effects for EPIDIOLEX for patients in clinical trials abound, such as these stated on the FDA website: "sleepiness, sedation and lethargy; elevated liver enzymes; decreased appetite; diarrhea; rash; fatigue, malaise and weakness; insomnia, sleep disorder and poor quality sleep; and infections." To date, it's true that the whole plant extract of cannabis has not been replicated, rivaled or improved upon by modern science. [12]
Anecdotally, and free of any known serious side-effects, the whole plant extract of CBD hemp oil and raw cannabis juice continue as the two most nutritionally superior delivery methods for the consumption of cannabinoids. Big pharma is lagging behind. The drug industry has yet to outsmart the sacred cannabis plant. And you can't fool mother nature!
One can almost hear the whispers within secret corridors of cannabis research labs all over the world as accelerating efforts are underway to biosynthesize endica and sativa derivatives into pharmaceutical drugs in the name of patents and financial gain. But something is amiss. Why should anyone patent parts of a plant that is already perfect? Cannabis has been used in ancient herbal tribal medicines for thousands of years. There is not a single known overdose of cannabis on the record.
Yet, after 70 years of modern day cannabis censorship, why is there only one drug approved for this angel of all plant? The war on cannabis has taken its toll, no doubt. Not much has been done in the name of medical validation and progress for this beloved and much needed natural herbal apothecary. Education is key, so we'll keep up the fight!
In conclusion, it appears for the most part that the abundance of the scientific medical findings surrounding cannabis treatments for mammals are kept under proprietary wraps. The clock is ticking. People and pets are sick and dying. Cannabis seems to offer hope. The earth mother gives us healing plants every day for FREE. It's man who attempts to control and exploit the medicinal values of herbs and plants. The the difference between profit-mongering pharmaceutical companies seeking to hoard plant-based potions is mother nature herself. Let's make a difference! Join our hemp crusade. Become a wholesale Touchstone Essentials affiliate for FREE today...
CLICK HERE
Cannabis is the rightful heirloom of the people! Long live cannabis! Get involved!
REFERENCES[1] https://en.wikipedia.org/wiki/Prostaglandin
[2] https://www.sciencedirect.com/science/article/abs/pii/0006295285903259?via%3Dihub
[3] https://www.sciencedirect.com/science/article/pii/S0031942218303819#undfig1
[4] https://www.sciencedirect.com/science/article/pii/S0031942218303819
[5] https://www.ncbi.nlm.nih.gov/pubmed/3754224
[6] https://www.inverse.com/article/58027-cannflavins-a-and-b-in-cannabis-anti-inflammatory
[7] https://en.wikipedia.org/wiki/Flavonoid
[8] https://www.news-medical.net/health/What-are-Flavonoids.aspx
[9] https://www.youtube.com/watch?v=bOcL42D3Y5s&t=875s
[10] https://weedmaps.com/learn/dictionary/flavonoid/
[11] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081099/
[12] https://www.fda.gov/news-events/press-announcements/fda-approves-first-drug-comprised-active-ingredient-derived-marijuana-treat-rare-severe-forms
[13] https://en.wikipedia.org/wiki/Flavonoid#Cancer
[14] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740396/
Tariq said, “These molecules are non-psychoactive and they target the inflammation at the source, making them ideal painkillers.” In fact, Tariq and his team of researchers drew the conclusion that they have found "A Pain-Killing Compound 30x Stronger Than Aspirin Is Produced in Cannabis." [6]
Although little is known about the pathway of their biosynthesis, Tariq is hopeful that patients of the future will have opioid-free choices with these two ideal cannflavins A & B for a potentially intense and targeted anti-inflammatory response. Tariq and colleagues have sucessfully isolated the two flavones. They managed to replicate them in synthetic form and patents are now pending for these two wonder flavones.
Regardless of whether or not you support or oppose the isolation of genetic plant compounds for exclusive private profiteering, the point remains that this is happening on a grand scale rather furiously as cannabis technologies unfold at a rapid pace. [6][11]
The way it looks we are only touching the tip of the iceberg concerning cannabis research and development for future holistic medicines. These two distinct flavonoids, cannflavin A & B found exclusively in cannabis are gaining attention for their superior anti-inflammatory potential in animal models.
Few controlled studies on humans have been designated for cannabis research of any nature, but over 10K preclinical studies exist for cannabis. Tragically to date, only one synthetic drug with a CBD-cannabidiol cannabis derivative has been approved by the FDA for seizure patients, called EPIDIOLEX. Little is known about the long-term possible drug side-effects of EPIDIOLEX. It's too early to tell. But the short-term side-effects for EPIDIOLEX for patients in clinical trials abound, such as these stated on the FDA website: "sleepiness, sedation and lethargy; elevated liver enzymes; decreased appetite; diarrhea; rash; fatigue, malaise and weakness; insomnia, sleep disorder and poor quality sleep; and infections." To date, it's true that the whole plant extract of cannabis has not been replicated, rivaled or improved upon by modern science. [12]
Anecdotally, and free of any known serious side-effects, the whole plant extract of CBD hemp oil and raw cannabis juice continue as the two most nutritionally superior delivery methods for the consumption of cannabinoids. Big pharma is lagging behind. The drug industry has yet to outsmart the sacred cannabis plant. And you can't fool mother nature!
One can almost hear the whispers within secret corridors of cannabis research labs all over the world as accelerating efforts are underway to biosynthesize endica and sativa derivatives into pharmaceutical drugs in the name of patents and financial gain. But something is amiss. Why should anyone patent parts of a plant that is already perfect? Cannabis has been used in ancient herbal tribal medicines for thousands of years. There is not a single known overdose of cannabis on the record.
Yet, after 70 years of modern day cannabis censorship, why is there only one drug approved for this angel of all plant? The war on cannabis has taken its toll, no doubt. Not much has been done in the name of medical validation and progress for this beloved and much needed natural herbal apothecary. Education is key, so we'll keep up the fight!
In conclusion, it appears for the most part that the abundance of the scientific medical findings surrounding cannabis treatments for mammals are kept under proprietary wraps. The clock is ticking. People and pets are sick and dying. Cannabis seems to offer hope. The earth mother gives us healing plants every day for FREE. It's man who attempts to control and exploit the medicinal values of herbs and plants. The the difference between profit-mongering pharmaceutical companies seeking to hoard plant-based potions is mother nature herself. Let's make a difference! Join our hemp crusade. Become a wholesale Touchstone Essentials affiliate for FREE today...
CLICK HERE
Cannabis is the rightful heirloom of the people! Long live cannabis! Get involved!
REFERENCES[1] https://en.wikipedia.org/wiki/Prostaglandin
[2] https://www.sciencedirect.com/science/article/abs/pii/0006295285903259?via%3Dihub
[3] https://www.sciencedirect.com/science/article/pii/S0031942218303819#undfig1
[4] https://www.sciencedirect.com/science/article/pii/S0031942218303819
[5] https://www.ncbi.nlm.nih.gov/pubmed/3754224
[6] https://www.inverse.com/article/58027-cannflavins-a-and-b-in-cannabis-anti-inflammatory
[7] https://en.wikipedia.org/wiki/Flavonoid
[8] https://www.news-medical.net/health/What-are-Flavonoids.aspx
[9] https://www.youtube.com/watch?v=bOcL42D3Y5s&t=875s
[10] https://weedmaps.com/learn/dictionary/flavonoid/
[11] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081099/
[12] https://www.fda.gov/news-events/press-announcements/fda-approves-first-drug-comprised-active-ingredient-derived-marijuana-treat-rare-severe-forms
[13] https://en.wikipedia.org/wiki/Flavonoid#Cancer
[14] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740396/